INNOVATIONS WITH PROVEN RESULTS!

 Based on many years of combined experiences of various scientists.

 Produces the most consistent, efficient experimental data and reduces data statistical     errors, with the innovative 2-D micro-controls, consistent contractile signal transduction,     fast tissue mounting (reducing tissue hypoxia), fixed tissue holding and stimulation     positions, etc.

 Eases tissue/organ studies in all phases of experiments: tissue mounting, oxygenation     control, preset tension, (stimulation), recording and data marking, waste disposal/washing,     and data analyses.

 Proprietary design, featuring modular, miniature tissue holders with embedded stimulation     Pt. electrodes, for various types and sizes of tissues and organs, in baths as small as 2ml.

 High sensitivity for isometric/isotonic tissue or organ studies, with a included bridge     amplifier, or an integrated amplifier/data acquisition system, or an separate data     acquisition system.

 Much lower system ($1K to $3K less for a 4-ch.) & drug costs than competitions.

 Suitable for studies of vascular rings (as small as 200ŚĚm), smooth/skeletal tissue strips,     cardiac tissues (atria, papillary, sinus node, etc.) , and other isolated tissues and organs,     on one or multiple channels.

The EZ-Bath™ features multiple innovative, proprietary functions that ease the tissue/organ studies, efficiently producing more consistent data than any other systems in the market. At the heart of the system is a versatile mounting platform, on a mounting/control (M/C) bracket, for studying distinct types and sizes of tissue or organ samples with ease. Among the innovative functions are consistent point-of-force application, reliable contractile signal transduction even for mini-contractile, tissue tension micro-adjustment (as fine as 5 microns, see McPherson, 1992), modular tissue holders with or without embedded miniature stimulation electrodes, and a multi-function adjustment feature. The multi-function adjustment is designed to ease tissue mounting and to accommodate different types and sizes of tissue preparations. The micro-adjustment features, along with other innovations, improve experimental consistency among different tissue channels and across different experiments, which is essential for statistical data analyses for bio-tissues/organs.

• Embedded Mini Electrodes On Tissue Holders for Consistent Stimulation,
   in stead of competitors' externally positioned electrodes or in-efficient electrodes    fabricated on glass chamber, introducing in-consistency among different tissue channels or    across experiments.

2. Versatility and Miniature Tissue Holders

The EZ-Bath™ features a series of proprietary, compact, exchangeable tissue mounting devices, the MV, LV, TSS and TSC™ series tissue holders. These holders relay accurately the mechanical tension, contractility, and mobility of tissues under study, have embedded stimulation electrodes that generate consistent stimulation actions, and are suitable, in a single platform of exchangeable mounting, for studying various bio-tissue preparations ranging from large/small/micro diameter vessel rings (as small as 200µm in i.d.), skeletal muscle spindles, smooth muscle strips, to atria and other organ/tissue preparations, in our jacketed tissue baths as small 2ml in volume.

(1). Reducing Tissue Hypoxia by Easing & Quickening Tissue Mounting

(2). Reducing Tissue Hypoxia by Easing & Quickening Tissue Mounting

The EZ-Bath™ system is compatible with transducers and/or bridge amplifiers manufactured by many other suppliers. For more information, please contact GlobalTown.

Reduce Costs! Add High Performance Data Acquisition and Analysis Functions
Option 1: EZ-Bath-4TAD: Organ Baths, Transducers, Integrated Amp/DAQ System BRAMDA-4
Option 2: EZ-Bath-4TBD: Organ Baths, Transducers, BRAM4, and i-DAQ4 or i-DAQ8

Alternatively, our portable, versatile data acquisition systems, i-DAQ4
and i-DAQ8, can be added as a separate system as needed for 4- or 8-channel EZ-Bath-4/8TBD with one BRAM4 or 2xBRAM4 bridge amplifiers.

In either configuration, all you need is a computer to start with highly efficient and consistent experiments, recording and data analyses!

The EZ-Bath-1TR consists of all the necessary components for study of one tissue/organ sample at a time. It includes all you need for a single tissue/organ experiments: a jacketed bath chamber, an isometric transducer, an M/C bracket with 2D micro adjustments, an aeration/stimulation manifold, vertical stainless steel rods, base plate, and accessories.

The EZ-Bath-1TB includes, in addition to all the components of EZ-Bath-1TR, a mini one-channel i-BRIDGE™ amplifier. Please contact us for more information at info@globaltowns.com.

REFERENCES:
Newcomer, S.C. et al. (2007). Comparative Biochem. and Physiol.¨CPart A, 148, 292-300
McAllister, R.M., et al. (2007). J. Appl. Physiol., 104, 186-197
Challinor-Rogers, J.L., et al. (1994). Naunyn-Schmiedeberg's Arch. Pharmacol.,
350, 158-166.
McPherson, G.A. (1992). Clin. Exp. Pharm. Physiol., 12, 815-825.
McPherson, G.A. and Piekarska, A.E. (1994). Br. J. Pharmacol. 112, 1223-1229.

Buffer Pre-Warming System Ease Tissue/Organ Bath Experiments

The buffer pre-warming system (PS) can be easily added to the EZ-Bath system (i.e. on the same base plate), without the need for extra space, to shorten the buffer-warming time and speed up experiments.