The EZ-Bath™, the most user friendly, cost-effective 4-channel tissue/organ bath systems in the market. The state-of-the-art tissue bath is designed, based on many years of combined experiences of various scientists. The EZ-Bath™ can be used for studies of vascular or non-vascular tissues, skeletal or smooth muscles, cardiac tissues/organs (e.g. atria, papillary, sinus node), and other isolated biological tissue or organ preparations. The EZ-Bath™ features multiple innovative, proprietary functions that ease the tissue/organ studies, efficiently producing more consistent data than any other systems in the market. At the heart of the system is a versatile mounting platform, on a mounting/control (M/C) bracket, for studying distinct types and sizes of tissue or organ samples with ease. Among the innovative functions are consistent point-of-force application, reliable contractile signal transduction even for mini-contractile, tissue tension micro-adjustment (as fine as 5 microns, see McPherson, 1992), modular tissue holders with or without embedded miniature stimulation electrodes, and a multi-function adjustment feature. The multi-function adjustment is designed to ease tissue mounting and to accommodate different types and sizes of tissue preparations. The micro-adjustment features, along with other innovations, improve experimental consistency among different tissue channels and across different experiments, which is essential for statistical data analyses for bio-tissues/organs.